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Expression of HORMAD1 in Chronic Rhinosinusitis and Its Correlation with Inflammatory Factors

Xin Zhang1, Yu Xu1, Jinhui Zhou1

  • 1Department of Otolaryngology Head and Neck Surgery, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, China.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|January 8, 2024
PubMed

Insights

HORMA domain containing protein 1 (HORMAD1) expression is elevated in chronic rhinosinusitis (CRS) patients, correlating with increased inflammatory factors. This suggests HORMAD1 may trigger inflammation, potentially improving CRS therapies.

Area of Science:

  • Immunology
  • Molecular Biology
  • Otorhinolaryngology

Background:

  • Chronic rhinosinusitis (CRS) is a prevalent inflammatory condition of the upper airway.
  • The role of specific proteins like HORMA domain containing protein 1 (HORMAD1) in CRS pathogenesis remains underexplored.
  • Understanding molecular markers is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the expression levels of HORMAD1 in patients diagnosed with chronic rhinosinusitis.
  • To determine the correlation between HORMAD1 expression and key inflammatory factors in CRS.
  • To assess the potential diagnostic value of HORMAD1 in CRS.

Main Methods:

  • An observational study involving 80 CRS patients and 80 healthy controls.
  • Quantitative real-time PCR (RT-qPCR) was utilized to measure HORMAD1 plasma levels.
  • Enzyme-linked immunosorbent assay (ELISA) was employed to quantify cytokine levels (IL-1β, TNF-α, IL-6, IFN-γ).

Main Results:

  • HORMAD1 expression was significantly upregulated in CRS patients compared to healthy individuals (AUC=0.9442).
  • Elevated levels of inflammatory cytokines, including IL-1β, TNF-α, IL-6, and IFN-γ, were observed in CRS patients.
  • A significant positive correlation was identified between HORMAD1 expression and the measured cytokines.

Conclusions:

  • HORMAD1 expression is abnormally high in chronic rhinosinusitis patients.
  • HORMAD1 may play a role in triggering the inflammatory response characteristic of CRS.
  • These findings could inform future therapeutic strategies for improving treatment efficacy in CRS.
Abstract

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