Association Between Remnant Cholesterol and Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography...

Area of Science:

• Cardiology
• Nephrology
• Clinical Chemistry

Background:

• Contrast-induced nephropathy (CIN) is a kidney complication following iodinated contrast media use.
• Remnant cholesterol (RC) is a marker for atherosclerotic cardiovascular disease (ASCVD) risk.

Purpose of the Study:

• To investigate the association between remnant cholesterol (RC) levels and the risk of contrast-induced nephropathy (CIN).
• To evaluate the impact of RC on clinical outcomes, including repeated revascularization, after coronary angiography (CAG) and/or percutaneous coronary intervention (PCI).

Main Methods:

• Retrospective analysis of 3332 consecutive patients undergoing CAG and/or PCI.
• Patients were stratified into four groups based on baseline RC levels.
• Statistical analysis, including quartile analysis and adjusted models, was used to assess associations.

Main Results:

• Initial quartile analysis suggested an association between RC levels (≤0.20 or ≥0.38 mmol/L) and increased CIN risk (P < .05).
• This association between RC and CIN was not significant after adjustment for other factors.
• A significant correlation was found between high RC levels (highest quartile) and repeated revascularization after PCI (aOR 4.06; P < .001), even after adjustment.

Conclusions:

• This study suggests that RC may not be an independent predictor of CIN after CAG/PCI.
• High RC levels are significantly associated with an increased risk of repeated revascularization in PCI patients.
• The complex clinical profile of patients, rather than RC alone, likely contributes to CIN risk in this population.