The causal relationship between psoriasis and artificial joint re-operation after arthroplasty: A two-sample...

Area of Science:

• Medical Genetics
• Epidemiology
• Orthopedic Surgery

Background:

• Psoriasis is linked to increased arthroplasty complications, but causality is unproven.
• Investigating the causal relationship between psoriasis and artificial joint re-operation is crucial.

Purpose of the Study:

• To explore the causal effect of psoriasis on artificial joint re-operation after arthroplasty.
• Utilizing two-sample Mendelian randomization (MR) to establish a genetic link.

Main Methods:

• Mendelian randomization (MR) analysis using genome-wide association study (GWAS) data.
• Psoriasis as exposure, with single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs).
• Validated findings using inverse variance weighted (IVW), MR Egger, weighted median, and MR-PRESSO methods.

Main Results:

• Psoriasis significantly increases the risk of artificial joint re-operation (OR = 1.12, p = 0.036).
• Consistent results across multiple MR analysis methods (weighted median, MR Egger, weighted mode).
• Sensitivity analyses confirmed no significant heterogeneity or directional pleiotropy.

Conclusions:

• Psoriasis demonstrates a potential causal effect on artificial joint re-operation post-arthroplasty.
• Further research is needed to understand the mechanisms underlying this association.