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Updated: Jul 6, 2025

Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
Tirzepatide-Induced Biphasic Anaphylactic Reaction: A Case Report
Zhexiang He1, Agborya N Tabe1, Sohaib Rana1
1Internal Medicine, Conway Regional Medical Center, Conway, USA.
Abstract:
Anaphylaxis is a rapid and severe reaction to a trigger that is characterized by skin, mucosal, and cardiorespiratory changes. A minority of patients exhibit a biphasic anaphylactic reaction (BAR). Tirzepatide is a dual incretin receptor analog approved for the treatment of type 2 diabetes mellitus (T2DM). Allergic reactions to tirzepatide were reported during clinical trials, but none were severe enough to be characterized as an anaphylactic reaction. We describe a case of a BAR to tirzepatide.
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