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Dilated cardiomyopathy in patients with hypoparathyroidism: A narrative review

Maryam Abdolmaleki1, Laya Ohadi1, Saba Maleki2

  • 1Shahid Beheshti University of Medical Sciences Tehran Iran.

Health Science Reports
|January 8, 2024
PubMed

Insights

Hypoparathyroidism can cause dilated cardiomyopathy (DCM), but timely calcium and vitamin D supplementation can reverse cardiac dysfunction. Patient adherence to treatment is key for managing this endocrine-related heart condition.

Area of Science:

  • Endocrinology
  • Cardiology

Background:

  • Hypoparathyroidism is a rare endocrine disorder marked by low calcium, high phosphorus, and insufficient parathyroid hormone.
  • This condition can lead to dilated cardiomyopathy (DCM), characterized by enlarged heart ventricles and impaired function.

Purpose of the Study:

  • To explore the link between hypoparathyroidism and DCM.
  • To investigate calcium's impact on cardiac function.
  • To assess the potential for DCM reversal with calcium supplementation.

Main Methods:

  • A comprehensive literature search was performed using PubMed and Google Scholar.
  • Included case reports of DCM in hypoparathyroidism patients.
  • Analyzed cases for cardiac manifestations, diagnostics, and management.

Main Results:

  • DCM in hypoparathyroidism presents with heart failure symptoms, reduced ejection fraction, and impaired left ventricular function.
  • Laboratory findings include low serum calcium and high phosphate levels.
  • Prompt treatment with calcium and vitamin D improved cardiac function.

Conclusions:

  • Hypoparathyroidism-induced DCM is reversible with timely calcium and vitamin D supplementation.
  • Patient compliance and regular monitoring are crucial for preventing cardiac complications.
  • Routine follow-up of DCM in endocrine disorder patients is recommended.
Abstract

Keywords:
calcium levelcalcium supplementationdilated cardiomyopathyhypoparathyroidism

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