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Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex
Zachary R Zeisler1,2, Kelsey A Heslin1, Frederic M Stoll1,2
1Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Biorxiv : the Preprint Server for Biology
|January 8, 2024
Summary
Brain connectivity differs between mice and macaques. Mouse basolateral amygdala (BLA) neurons project to more frontal cortex (FC) areas than macaque BLA neurons, revealing species-specific neural pathways.
Area of Science:
- Neuroscience
- Comparative Anatomy
- Connectomics
Background:
- The basolateral amygdala (BLA) is crucial for emotional processing and decision-making.
- BLA projections to the frontal cortex (FC) are implicated in these functions in both rodents and primates.
- However, the precise comparative organization of these single-neuron BLA-FC projections remains largely unexplored.
Conclusions:
- The comparative organization of single-neuron BLA-FC projections differs substantially between rodents (mice) and primates (macaques).
- These findings highlight species-specific variations in neural circuitry, particularly in the pathways connecting emotion and executive function centers.
