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Intraperitoneal hyaline vascular Castleman disease: Three case reports
Jia-Wei Gao1, Zhe-Yi Shi1, Zhao-Bi Zhu1
1Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China.
Insights
Castleman disease (CD) is a rare lymphoproliferative disorder with varied symptoms, making diagnosis challenging. Accurate diagnosis, often relying on pathology, is crucial for appropriate treatment of this complex condition.
Area of Science:
- Oncology
- Pathology
Background:
- Castleman disease (CD) is a rare, non-malignant lymphoproliferative disorder with an unclear cause.
- Varied clinical presentations complicate the diagnosis and treatment of CD.
Observation:
- This report reviews three cases of intraperitoneal Castleman disease diagnosed between January 2018 and June 2023.
- Patients underwent clinical, paraclinical, histopathological, and immunohistochemical examinations.
Findings:
- All three patients were definitively diagnosed with Castleman disease.
- Diagnosis relied on routine histopathological and immunohistochemical findings due to a lack of specific symptoms or lab abnormalities.
Implications:
- Castleman disease is a complex and rare entity requiring precise diagnosis.
- Histopathological and immunohistochemical analyses are essential for diagnosing CD.
- Accurate diagnosis is key to selecting effective treatment strategies for patients with Castleman disease.
Background:
Castleman disease (CD) was first reported in 1954. It is a rare non-malignant lymphoproliferative disease with unclear etiology. As the clinical manifestations of CD are different, there are difficulties in its diagnosis and treatment. Therefore, for patients with CD, it is important to establish the diagnosis in order to choose the appropriate treatment.
Case Summary:
In this report, three patients with intraperitoneal CD treated at our center from January 2018 to June 2023 were reviewed, and the clinical and paraclinical examinations, diagnosis, and treatment were analyzed, and all three patients were diagnosed with CD by routine histopathological and immunohistochemical examinations.
Conclusion:
CD is a complex and rare disease. Because there are no special clinical symptoms and laboratory abnormalities, the diagnosis often depends on routine pathological and immunohistochemical findings.
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