Related Experiment Video
Updated: Jul 19, 2026
In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis
Published on: October 20, 2013
Giant PMMA Foreign Body Granulomas with Imaging.
Sunthosh Sivam1, Christine Mackay2, Clinton Humphrey2
1Baylor College of Medicine, Houston, TX, USA.
Giant foreign body granulomas, a rare complication of polymethylmethacrylate (PMMA) filler, can develop years later. Intralesional injections of triamcinolone acetonide and 5-fluorouracil effectively treated this delayed filler complication.
Area of Science:
- Dermatology
- Plastic Surgery
- Radiology
Background:
- Filler complications encompass diverse presentations, with foreign body granulomas representing a rare late manifestation.
- Polymethylmethacrylate (PMMA) is a dermal filler known for its longevity and potential for delayed adverse reactions.
Observation:
- A case of giant foreign body granulomas emerged 7 years post-PMMA injection.
- Magnetic resonance imaging (MRI) provided unique pre- and post-treatment visualization of granuloma expansion and therapeutic response.
Findings:
- Intralesional triamcinolone acetonide and 5-fluorouracil demonstrated excellent efficacy in resolving the giant foreign body granulomas.
- The treatment resulted in significant reduction of granuloma size and associated inflammatory changes.
Implications:
- This case highlights effective management strategies for rare, late-onset filler complications.
- Non-surgical intralesional therapies are recommended as first-line treatments, reserving surgical excision for refractory cases.
More Related Videos
10:04Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
12:15Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease
Published on: February 8, 2022
