Related Experiment Video
Updated: Jul 6, 2025
07:09
Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
Published on: April 1, 2015
11.5K
Hypercoagulability in Sickle Cell Disease: A Thrombo-Inflammatory Mechanism
1Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Gizan, Saudi Arabia.
Hemoglobin
|January 8, 2024
Summary
Sickle cell disease (SCD) causes blood clotting issues due to abnormal hemoglobin S. Understanding this hypercoagulable state is key to explaining SCD
Area of Science:
- Hematology
- Molecular Biology
- Pathophysiology
Background:
- Sickle cell disease (SCD) is an inherited blood disorder.
- SCD involves abnormal hemoglobin S, leading to red blood cell sickling.
- Complications include anemia, hemolysis, pain, vaso-occlusion, and thrombosis.
Purpose of the Study:
- To explore the multifactorial causes of hypercoagulability in SCD.
- To elucidate the molecular basis of hemoglobin S driving hypercoagulability.
- To understand the thrombo-inflammatory mechanisms in SCD pathogenesis.
Main Methods:
- Review of existing literature on SCD pathophysiology.
- Analysis of molecular mechanisms of hemoglobin S.
- Examination of hemostatic system alterations in SCD patients.
Main Results:
- Hemoglobin S is the primary driver of hypercoagulability in SCD.
- Sickling, hemolysis, and oxidative stress activate platelets and coagulation.
- These processes deplete inhibitors and promote microvesicle formation.
Conclusions:
- Hypercoagulability in SCD is a complex thrombo-inflammatory process.
- Understanding these mechanisms explains SCD pathogenesis and complications.
- Targeting these pathways may offer therapeutic strategies.
Keywords:
Sickle cell diseasehemoglobin Shemostasishypercoagulabilityinflammationthrombo-inflammatoryMore Related Videos
Related Concept Videos
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
701
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
701
01:49Multiple Allele Traits
34.2K
The Concept of Multiple Allelism
34.2K
01:24Disorders of Hemostasis
918
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
918
01:20Extrinsic and Intrinsic Pathways of Hemostasis
7.7K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
7.7K
01:05Introduction to Hemostasis
7.8K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
7.8K
01:09Coagulation
6.7K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
6.7K