Opioid prescription patterns in a children's hospital from 2012 to 2016

Nicole Titze1, Rishi Bhargava2, Ara Jamasbi Montalvo3

  • 1Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrence, California.

PubMed

Insights

Pediatric opioid prescriptions decreased significantly from 2012 to 2016. Increased age and longer hospital stays were linked to more pain medication prescriptions, highlighting evolving pediatric pain management strategies.

Area of Science:

  • Pediatric pharmacology
  • Pain management
  • Public health

Background:

  • The opioid epidemic has increased opioid use in adults.
  • Pediatric pain management requires careful consideration due to potential risks.
  • Understanding trends in pediatric analgesic prescribing is crucial.

Purpose of the Study:

  • To analyze trends in narcotic and non-narcotic pain medication prescriptions in pediatric patients.
  • To identify changes in pediatric pain management over time.
  • To examine factors associated with opioid prescription in children and adolescents.

Main Methods:

  • Analysis of 58,402 analgesic prescriptions for patients aged 0-21 years (May 2012-November 2016).
  • Logistic regression model to assess the association of age, sex, diagnosis, and hospital stay length with opioid prescription probability.
  • Retrospective review of prescription data from a large pediatric hospital.

Main Results:

  • A statistically significant reduction in opioid prescriptions was observed from 2012 to 2016 (p < 0.001).
  • Increased age and longer hospital stays were directly associated with higher probabilities of opioid prescription (p < 0.001).
  • Demographic shifts noted, with a male predominance in younger patients (<15 years) and a female predominance in older adolescents (>16 years).

Conclusions:

  • Overall opioid prescriptions decreased in pediatric patients, potentially due to FDA regulations and increased awareness of opioid-related harms.
  • Age and length of hospital stay are significant factors influencing analgesic prescribing patterns.
  • Further research is warranted to explore specific opioid prescription patterns within the pediatric population.
Abstract

Related Concept Videos

Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
734
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
300
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
251
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
625
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents01:17

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
203