Related Experiment Video

Updated: Jul 6, 2025

Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions
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Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions

Published on: February 24, 2021

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TBC1D1 represses glioma progression by altering the integrity of the cytoskeleton

Jiahong Cai1, Yong'an Jiang1, Peng Chen1

  • 1Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi, China.

Aging
|January 8, 2024
PubMed
Abstract

Insights

High TBC1D1 expression correlates with poor glioma prognosis. Inhibiting TBC1D1 reduces glioma cell proliferation, migration, and invasion by affecting the actin cytoskeleton, suggesting TBC1D1 as a potential therapeutic target.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Glioma is an aggressive brain tumor with poor prognosis.
  • TBC1D1 is linked to various cancers, but its role in glioma is unknown.

Purpose of the Study:

  • To investigate the role of TBC1D1 in glioma development and prognosis.
  • To explore TBC1D1 as a potential therapeutic target for glioma.

Main Methods:

  • Analyzed TBC1D1 expression in glioma patient data (CGGA, TCGA).
  • Assessed TBC1D1's effect on glioma cell viability, proliferation, migration, and invasion in vitro.
  • Investigated the P-LIMK/cofilin pathway and actin cytoskeleton dynamics.

Main Results:

  • High TBC1D1 expression is associated with poor glioma prognosis.
  • Downregulating TBC1D1 inhibited glioma cell proliferation, migration, and invasion.
  • TBC1D1 affects actin cytoskeleton integrity via the P-LIMK/cofilin pathway.

Conclusions:

  • TBC1D1 influences glioma cell aggressiveness by altering actin cytoskeleton balance.
  • TBC1D1 represents a potential therapeutic target for glioma treatment.
Keywords:
TBC1D1cytoskeletongliomainvasionmigration

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