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Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
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Circulating Tumor DNA in the Immediate Postoperative Setting.

Vasileios Efthymiou1, Natalia Queenan1, Markus Haas1

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Detecting circulating tumor DNA (ctDNA) shortly after surgery accurately predicts cancer recurrence risk. This biomarker shows potential for guiding adjuvant treatment decisions in various solid tumors.

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Area of Science:

  • Oncology
  • Molecular Diagnostics
  • Cancer Biomarkers

Background:

  • Circulating tumor DNA (ctDNA) is a real-time biomarker for disease status in solid tumors.
  • Current ctDNA utility studies often miss early adjuvant treatment decision points.
  • This review assesses ctDNA feasibility as a biomarker in the immediate postoperative period.

Approach:

  • Systematic review of literature.
  • Focused on early ctDNA kinetics within 3 days post-surgery.
  • Included patients undergoing curative-intent surgery.

Key Points:

  • Eight cohort studies (from 2057 identified) met evaluation criteria.
  • Six cancer types were analyzed.
  • All studies indicated higher recurrence risk with detectable postoperative ctDNA.

Conclusions:

  • Postoperative ctDNA detectability predicts recurrence across cancer types.
  • Early postoperative ctDNA may guide minimal residual disease assessment.
  • Further research needed for precise ctDNA kinetics and optimal timing across tumor types.