Effect of ozone gas on viral kinetics and liver histopathology in hepatitis C patients
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Ahmed Sadek1, Ahmed M Abd El Hady2, Hammam Olfat2
1Departments of Hepatology & Gastroenterology, Theodor Bilharz Research Institute, Giza, Egypt.
Objectives:
We examine how well ozone/oxygen gas therapy treats chronic hepatitis C patients with varying degrees of liver fibrosis. Also to study the effect of giving multiple anti-oxidants with the ozone/oxygen gas mixture, to see if this addition would have any additive or synergistic effect.
Methods:
Two hundred and twenty three patients with chronic hepatitis C. Liver biopsies were carried out at after 12 weeks of administering an ozone/oxygen gas mixture.
Results:
The mean stage of fibrosis decreased from 1.98 to 1.41 and the mean grade of inflammation decreased from 10.08 to 7.94, both with a p value less than 0.001. After 12 weeks of treatment, mean PCR values increased. No single significant complication was recorded in a total of >9,000 settings of ozone therapy.
Conclusions:
Ozone oxygen gas mixture is safe and effective in treatment of hepatic fibrosis due to chronic viral hepatitis C.
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