Hyperkeratosis lenticularis perstans (Flegel's disease). Case report and literature review

A case of Flegel's disease, or hyperkeratosis lenticularis perstans, is reported. This rare chronic disorder is characterized by asymptomatic hyperkeratotic papules, usually located on the lower extremities. Most reported cases have been from Europe. We report a case of hyperkeratosis lenticularis perstans from our institution that was treated successfully with topical 5-fluorouracil.