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Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Remodeling01:40

Bone Remodeling

38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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What is the Skeletal System?01:02

What is the Skeletal System?

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Overview
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.3K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Related Experiment Video

Updated: Jul 6, 2025

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

536

Osteoporosis.

Kristine E Ensrud1, Carolyn J Crandall2

  • 1University of Minnesota, Minneapolis, Minnesota (K.E.E.).

Annals of Internal Medicine
|January 8, 2024
PubMed
Summary

Osteoporosis screening identifies patients needing fracture prevention medication. Optimizing pharmacotherapy timing, choice, and duration maximizes benefits while minimizing drug risks.

Area of Science:

  • Gerontology
  • Orthopedics
  • Pharmacology

Background:

  • Osteoporosis is a prevalent skeletal disorder characterized by bone fragility.
  • Increased fracture risk is a primary consequence of osteoporosis.
  • Effective screening strategies are crucial for identifying at-risk individuals.

Purpose of the Study:

  • To highlight the importance of evidence-based screening for osteoporosis.
  • To emphasize optimizing pharmacotherapy for fracture prevention.
  • To balance treatment benefits against potential long-term drug harms.

Main Methods:

  • Review of evidence-based screening strategies for osteoporosis.
  • Analysis of factors influencing pharmacotherapy decisions in osteoporosis management.

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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

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  • Evaluation of risk-benefit profiles for osteoporosis medications.

    • Main Results:

    • Screening improves the identification of patients likely to benefit from treatment.
    • Strategic pharmacotherapy initiation, selection, and duration are key to maximizing fracture prevention.
    • Careful management minimizes adverse effects associated with long-term drug use.

    Conclusions:

    • Evidence-based screening is essential for targeted osteoporosis treatment.
    • Personalized pharmacotherapy approaches enhance fracture prevention efficacy.
    • Balancing treatment benefits and harms is critical for long-term patient outcomes.