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Pulmonary complications following methotrexate therapy
Abstract:
Methotrexate is frequently used in the treatment of severe psoriasis, and its hepatotoxicity has long been recognized by dermatologists. Pulmonary complications resulting from use of the drug are uncommon but should be considered in any patient on methotrexate who develops pulmonary symptoms in the absence of infection. We describe two patients, one who developed an acute pneumonitis and one with progressive pulmonary fibrosis following long-term, low-dose methotrexate for psoriasis. Early recognition of these complications by lung function testing and withdrawal of the drug, when necessary, may arrest or reverse methotrexate-induced lung disease.
Insights
Methotrexate, used for psoriasis, can cause rare but serious lung issues like pneumonitis and fibrosis. Early detection through lung function tests and stopping the drug may reverse these methotrexate-induced lung diseases.
Area of Science:
- Pulmonology
- Dermatology
- Pharmacology
Background:
- Methotrexate is a common treatment for severe psoriasis.
- Hepatotoxicity is a known side effect of methotrexate.
- Pulmonary complications are uncommon but serious adverse effects.