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Roles and signaling pathways of CITED1 in tumors: overview and novel insights

Wenting Chen1,2, Jianing Jiang1,2, Jinqi Gao3

  • 1Department of Oncology Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.

The Journal of International Medical Research
|January 8, 2024
PubMed

Insights

CBP/p300 interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 (CITED1) is a transcriptional co-regulator involved in embryonic development and tumor progression. This review covers CITED1's biological roles, signaling pathways, and potential in cancer diagnosis and treatment.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Gene Regulation

Background:

  • CBP/p300 interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 (CITED1) is a transcriptional co-regulator.
  • It lacks DNA-binding capacity but interacts with CBP/p300 co-activators via its CR2 domain.

Purpose of the Study:

  • To review the biological characteristics of CITED1.
  • To examine its role in regulating diverse signaling pathways.
  • To explore its potential in tumor diagnosis and treatment.

Main Methods:

  • Literature review of CITED1's functions.
  • Analysis of its involvement in key signaling pathways (TGF-β/BMP/SMAD, Estrogen, Wnt-β-catenin, Androgen-AR).
  • Evaluation of its role in embryonic development and tumorigenesis.

Main Results:

  • CITED1 regulates multiple signaling pathways crucial for development and cancer.
  • It plays a significant role in the occurrence and progression of various tumors.
  • Its biological characteristics and expression regulation are critical for its function.

Conclusions:

  • CITED1 is a key transcriptional co-regulator with implications in embryonic development.
  • Its dysregulation is linked to various cancers, suggesting potential as a diagnostic and therapeutic target.
  • Further research into CITED1's pathways can advance cancer treatment strategies.
Keywords:
CBP/p300 interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 (CITED1)diagnosisprognosistransactivationtranscriptiontreatmenttumor

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