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[Diagnosis and Treatment of Lambert-Eaton Myasthenic Syndrome]

Hiroko Kitanosono¹, Shunsuke Yoshimura, Hirokazu Shiraishi

¹Department of Neurology, Nagasaki Prefecture Shimabara Hospital.

Brain and Nerve = Shinkei Kenkyu No Shinpo

|January 8, 2024

Abstract:

Approximately 90% of patients with Lambert-Eaton myasthenic syndrome (LEMS) show positive P/Q-type voltage-gated calcium channels antibodies, which can be broadly classified clinically as paraneoplastic, particularly with small cell lung carcinoma and non-paraneoplastic without cancer. The first Japanese guideline for LEMS was developed in May 2022 as MG/LEMS Practice Guideline 2022. This article describes the epidemiology, symptoms, diagnosis, examination, treatment, and prognosis of this condition, based on the LEMS guidelines.

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