Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

In vitro inhibition of Escherichia coli β-glucuronidase by aripiprazole.

Pharmacological reports : PR·2026

Same author

Dual-mechanism vitamin C delivery by polyethylene glycol-23 glyceryl distearate-based niosomes via SVCT2 induction and enhanced transdermal penetration.

Drug delivery·2026

Same author

Lactated Ringer's Solution at a Standard Infusion Rate in Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis Prevention: A Retrospective Comparative Study.

Digestive diseases and sciences·2026

Same author

Effectiveness and Safety of Enteroscopy-Assisted ERP-Guided Versus EUS-Guided Pancreatic Duct Drainage for Pancreaticojejunostomy Strictures: A Multicenter Observational Study.

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society·2026

Same author

Association of Liver Immune Status Index With the Nutritional Status and Prognosis in Patients With Cirrhosis.

In vivo (Athens, Greece)·2026

Same author

Perfectly harmonic spin cycloid and multi-Q textures in the Weyl semimetal GdAlSi.

Nature communications·2026

Search research articles

Related Experiment Video

Updated: Jul 6, 2025

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

Paternal methamphetamine exposure differentially affects first and second generations in mice.

Sakiko Munetomo-Aoki¹, Asuka Kaizaki-Mitsumoto¹, Ryota Nakano²

¹Department of Toxicology, Showa University Graduate School of Pharmacy.

The Journal of Toxicological Sciences

|January 8, 2024

Summary

Paternal methamphetamine (METH) exposure impacts offspring development and behavior across generations. This study reveals lasting effects on F1 and F2 mice, highlighting the importance of paternal health on descendants.

Keywords:

Behavior Descendants Development Methamphetamine POHaD

More Related Videos

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Published on: July 13, 2014

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Published on: July 12, 2024

Related Experiment Videos

Last Updated: Jul 6, 2025

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Published on: July 13, 2014

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Published on: July 12, 2024

Area of Science:

Neuroscience
Toxicology
Genetics

Background:

Amphetamine-type stimulants, particularly methamphetamine (METH), are widely abused globally.
The paternal origin of health and disease theory suggests paternal factors influence offspring health.
Limited research exists on the transgenerational effects of paternal METH exposure on descendants.

Purpose of the Study:

To investigate the effects of paternal METH exposure on the growth, behavior, and neurobiology of first (F1) and second (F2) filial generations in a mouse model.
To explore generational differences in the impact of paternal METH exposure.
To identify potential molecular mechanisms underlying these transgenerational effects.

Main Methods:

Male mice (sires) were administered METH for 21 days before mating.
Offspring (F1) underwent growth and behavioral assessments, including locomotion, memory, and anxiety tests.
RNA sequencing of the striatum was performed on male F1 mice.
F1 male mice were bred to produce F2 mice, which underwent similar behavioral testing.

Main Results:

Paternal METH exposure led to delayed growth and impaired memory in F1 mice.
F2 mice exhibited overweight conditions, reduced METH sensitivity, and decreased anxiety in females.
Gene enrichment analysis revealed significant behavioral terms in F1 and protein folding terms in F2 offspring.

Conclusions:

Paternal METH exposure induces multi-generational effects on offspring, with varying impacts across F1 and F2 generations.
These findings underscore the necessity of evaluating paternal environmental exposures beyond the immediate offspring.
Further research is warranted to explore the long-term epigenetic and molecular consequences in subsequent generations.