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Published on: November 5, 2019
Unusual non-infectious cause of meningitis
Pradeep Shrestha1, Buddhi Paudyal1, Lucky Sharma2
1Rheumatology Unit, Department of Internal Medicine, Patan Academy of Health Sciences, Lalitpur, Nepal.
Abstract:
Meningitis, though commonly caused by various infectious agents, may also have non-infectious aetiologies. The clinical presentation, however may be identical to infectious meningitis. We present a case of a female in her 50s who presented with fever, headache, vomiting and neck rigidity. She had features of inflammatory polyarthritis, cold sensitivity, puffy digits, alopecia and easy fatigability. No evidence of infection was found, and serological features consistent with mixed connective tissue disease (MCTD) were revealed, which led to the diagnosis of MCTD-related aseptic meningitis.
Insights
Aseptic meningitis can mimic infectious causes. This case highlights mixed connective tissue disease (MCTD) as a non-infectious cause of meningitis, presenting with typical symptoms but lacking infection.
Area of Science:
- Rheumatology
- Neurology
- Immunology
Background:
- Meningitis is typically caused by infections, but non-infectious causes exist.
- Non-infectious meningitis can present with symptoms indistinguishable from infectious meningitis.
- Mixed connective tissue disease (MCTD) is an autoimmune disorder with overlapping features of other connective tissue diseases.
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