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Updated: Jul 6, 2025

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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Deciphering the role of neddylation in tumor microenvironment modulation: common outcome of multiple signaling

Dequan Liu1, Xiangyu Che2, Guangzhen Wu3

  • 1Department of Urology, the First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.

Biomarker Research
|January 8, 2024
PubMed

Insights

Neddylation, a key process in tumor growth, can be targeted for cancer therapy. Inhibiting neddylation with MLN4924 shows promise in treating various cancers, especially when combined with other therapies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Neddylation is a post-translational modification crucial for biological processes.
  • Aberrant neddylation is implicated in cancer development and progression.
  • Neddylation influences tumor microenvironment components like immune cells and angiogenesis.

Purpose of the Study:

  • To review the molecular mechanisms of neddylation in modulating the tumor microenvironment.
  • To highlight the therapeutic potential of targeting neddylation, specifically CRLs.
  • To summarize the efficacy of MLN4924, a neddylation inhibitor, in cancer treatment.

Main Methods:

  • Review of current literature on neddylation and its role in cancer.
  • Investigation of MLN4924's inhibitory effects on neddylation.
  • Summary of therapeutic outcomes for MLN4924 in various tumor types.

Main Results:

  • Neddylation generally promotes tumor progression and malignancy.
  • Targeting neddylation, particularly CRLs, offers a promising therapeutic strategy.
  • MLN4924 effectively inhibits neddylation and has shown success in combination therapies for hematological and solid tumors.

Conclusions:

  • Neddylation plays a critical role in tumorigenesis and the tumor microenvironment.
  • MLN4924 represents a significant advancement in neddylation-targeted cancer therapy.
  • Combined therapeutic approaches involving MLN4924 demonstrate notable efficacy across diverse cancers.
Keywords:
Clinical trialsMLN4924NEDD8NeddylationSignaling pathwayTME

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