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Effectiveness of Baricitinib in Treating Atopic Dermatitis in Difficult-to-treat Areas: A Retrospective Real-world Study.

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Updated: Jul 10, 2026

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Published on: September 26, 2019

Considerations for managing elderly patients with atopic dermatitis.

Maddalena Napolitano1, Luca Potestio1, Mariateresa Nocerino1

  • 1Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Expert Review of Clinical Immunology
|January 9, 2024
PubMed
Summary

Diagnosing and managing atopic dermatitis (AD) in elderly patients is difficult due to varied symptoms and lack of biomarkers. New treatments offer hope, but more safety data is needed for certain therapies.

Keywords:
Atopic dermatitisclinical featureselderlypathogenesistherapies

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Area of Science:

  • Dermatology
  • Geriatrics
  • Immunology

Background:

  • Atopic dermatitis (AD) diagnosis in the elderly is challenging due to clinical polymorphism and absent biomarkers.
  • Aging-related immunosenescence, barrier alterations, and inflammaging complicate AD presentation and management in older adults.
  • Elderly-type AD is increasingly recognized, presenting unique diagnostic and therapeutic hurdles.

Purpose of the Study:

  • To review current knowledge on the pathogenesis, clinical presentation, and treatment of atopic dermatitis in elderly patients.
  • To highlight the diagnostic challenges and management difficulties associated with elderly-type AD.
  • To discuss emerging therapeutic options and the need for further safety data.

Main Methods:

  • A narrative review of existing literature was conducted.
  • Databases searched included PubMed, Medline, Embase, and Cochrane Skin.
  • Keywords focused on atopic dermatitis, clinical phenotypes, eczema, and elderly patients.

Main Results:

  • Elderly-type AD is an emerging entity with increasing prevalence.
  • Older patients may exhibit distinct immunophenotypes, complicating diagnosis.
  • Current systemic therapies are often contraindicated or poorly tolerated in the elderly, leading to undertreatment.

Conclusions:

  • Managing elderly-type AD requires addressing challenges in diagnosis and treatment.
  • Biologics like dupilumab and tralokinumab show promise.
  • Further research on the safety of JAK inhibitors in this population is crucial.