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The role of basic leucine zipper transcription factor E4BP4 in cancer: a review and update

Liang Wang1, Peifen Li1, Xueying Zhang1

  • 1Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, School of Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China.

Molecular Biology Reports
|January 9, 2024
PubMed

Insights

Nuclear transcription factor E4BP4 (E4BP4) impacts tumor growth and immune response. Targeting E4BP4 shows promise for enhancing cancer immunotherapy and overcoming drug resistance.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Tumor development is driven by genetic mutations and immune microenvironment dysregulation.
  • Nuclear transcription factor E4BP4 (E4BP4) is frequently dysregulated in various cancers.
  • E4BP4 influences cancer cell processes and the tumor immune microenvironment.

Purpose of the Study:

  • To review the molecular mechanisms of E4BP4 in cancer.
  • To explore E4BP4's role in cancer immunotherapy.
  • To examine E4BP4's impact on antitumor drug resistance.

Main Methods:

  • Literature review of studies on E4BP4 in cancer.
  • Analysis of E4BP4's transcriptional targets and signaling pathways.
  • Examination of E4BP4's role in immune cell regulation and drug resistance.

Main Results:

  • E4BP4 regulates key genes involved in cell proliferation and apoptosis.
  • E4BP4 modulates the tumor immune microenvironment, including NK cells and Th17 cells.
  • E4BP4 expression is linked to inhibition of multidrug resistance genes.

Conclusions:

  • E4BP4 plays a multifaceted role in cancer progression, immune evasion, and drug resistance.
  • Targeting E4BP4 presents a potential therapeutic strategy for cancer treatment.
  • Further research into E4BP4 mechanisms can inform novel antitumor strategies.
Keywords:
Cancer cellular processCancer immunotherapyChemotherapy resistanceE4 promoter-binding protein 4 (E4BP4)

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