Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A structurally abnormal insulin causing human diabetes.

H Tager, B Given, D Baldwin

    Nature
    |September 13, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chairside synopsis for children.

    British dental journal·2023
    Same author

    Quantitative blood loss after vaginal delivery: a retrospective analysis of 104 079 measurements at 41 institutions.

    International journal of obstetric anesthesia·2022
    Same author

    Dietary patterns, beliefs and behaviours among individuals with inflammatory bowel disease: a cross-sectional study.

    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2020
    Same author

    Ruptured Superficial Femoral Artery Anastomotic Pseudoaneurysm after 30 Years.

    Case reports in vascular medicine·2019
    Same author

    Reaction times of children having nitrous oxide inhalation sedation for dental procedures.

    European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2019
    Same author

    Case reports of atrial and pericardial rupture from blunt cardiac trauma.

    Journal of cardiothoracic surgery·2018
    Same journal

    Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

    Nature·2026
    Same journal

    China boosts prestigious grants for young scientists - will it ease competition?

    Nature·2026
    Same journal

    Incoming US science academy chief vows to 'double down' on research.

    Nature·2026
    Same journal

    Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

    Nature·2026
    Same journal

    Electrodeposited self-assembled molecules for perovskite photovoltaics.

    Nature·2026
    Same journal

    Neutrino's nursery found: the 'Shadow Blaster'.

    Nature·2026
    See all related articles

    Diabetic patient insulin had reduced receptor binding and glucose transport activity. Chemical analysis revealed a mix of normal insulin and an abnormal variant with a leucine substitution in the B-chain.

    Area of Science:

    • Biochemistry
    • Endocrinology
    • Molecular Biology

    Background:

    • Diabetes mellitus is characterized by impaired glucose regulation.
    • Hyperinsulinaemia, often observed in diabetes, suggests a potential issue with insulin function or signaling.
    • Understanding insulin's molecular structure and receptor interactions is crucial for metabolic research.

    Observation:

    • Insulin from a diabetic patient with fasting hyperinsulinaemia exhibited diminished binding to cell membrane insulin receptors.
    • The isolated insulin demonstrated reduced efficacy in stimulating cellular 2-deoxyglucose transport.
    • Impaired glucose oxidation was also noted in response to the patient's insulin.

    Findings:

    • Chemical analysis indicated the patient's insulin was a heterogeneous mixture.

    Related Experiment Videos

  • The mixture comprised normal insulin and an abnormal insulin variant.
  • The abnormal variant featured a specific amino acid substitution: leucine replacing phenylalanine at position 24 or 25 of the insulin B-chain.

    • Implications:

    • This structural abnormality in insulin may explain the observed functional deficits.
    • Identifying specific insulin variants can improve understanding of diabetes pathogenesis.
    • Such findings could inform the development of targeted therapies for specific diabetic subtypes.