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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-IV: Nursing Management01:30

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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Related Experiment Video

Updated: Jul 6, 2025

A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion
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Mind over asthma.

Wei Wong1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|January 9, 2024
PubMed
Summary

Janus kinase 1 (JAK1) in lung-innervating vagal sensory nerves suppresses allergic inflammation and asthma. This finding reveals a novel therapeutic target for respiratory diseases.

Area of Science:

  • Immunology
  • Neuroscience
  • Respiratory Medicine

Background:

  • Allergic inflammation and asthma are significant global health burdens.
  • Vagal sensory nerves play a role in respiratory functions and inflammation.
  • Janus kinase (JAK) signaling pathways are implicated in inflammatory responses.

Purpose of the Study:

  • To investigate the role of Janus kinase 1 (JAK1) in vagal sensory nerves.
  • To determine the effect of JAK1 on allergic inflammation in the lungs.
  • To explore JAK1 as a potential therapeutic target for asthma.

Main Methods:

  • Utilized mouse models of allergic asthma.
  • Employed genetic and pharmacological inhibition of JAK1 in vagal sensory neurons.
  • Assessed inflammatory markers, airway hyperresponsiveness, and immune cell infiltration in lung tissue.

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Main Results:

  • JAK1 expression was detected in vagal sensory nerves innervating the lungs.
  • Inhibition of JAK1 in these nerves significantly reduced allergic airway inflammation.
  • Blocking JAK1 activity attenuated airway hyperresponsiveness in asthma models.

Conclusions:

  • JAK1 in vagal sensory nerves acts as a suppressor of allergic lung inflammation.
  • Targeting JAK1 in the vagal sensory pathway offers a potential novel therapeutic strategy for asthma.