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Pathogenesis of Campylobacter fetus infections: serum resistance associated with high-molecular-weight surface

M J Blaser, P F Smith, J A Hopkins

    The Journal of Infectious Diseases
    |April 1, 1987
    PubMed

    Insights

    Most Campylobacter fetus strains are resistant to human serum due to surface proteins. This serum resistance is linked to specific protein bands and type A lipopolysaccharide, impacting illness presentation.

    Area of Science:

    • Microbiology
    • Immunology
    • Infectious Diseases

    Background:

    • Campylobacter fetus subspecies fetus causes systemic and diarrheal illnesses in humans.
    • Underlying conditions are more prevalent in patients with systemic C. fetus infections compared to fecal infections.

    Purpose of the Study:

    • To investigate the relationship between serum resistance and surface proteins in Campylobacter fetus.
    • To identify factors contributing to the pathogenicity of C. fetus subspecies fetus.

    Main Methods:

    • Studied 38 strains of C. fetus from 34 patients.
    • Assessed serum susceptibility using standardized assays.
    • Analyzed protein profiles using polyacrylamide gel electrophoresis.
    • Investigated the association between protein bands, lipopolysaccharide type, and serum resistance.

    Main Results:

    • 71% of C. fetus strains exhibited resistance to normal human serum.
    • Serum-resistant strains predominantly possessed major protein bands at 100 kDa or 125 kDa.
    • These protein bands were associated with type A lipopolysaccharide and surface exposure.
    • A spontaneous mutant lacking the 100-kDa protein band became serum sensitive.

    Conclusions:

    • Serum resistance is a common characteristic of human C. fetus isolates.
    • Cross-reactive surface proteins (100-kDa and 125-kDa) are strongly associated with serum resistance in C. fetus.
    • These surface proteins may play a crucial role in the pathogenesis of C. fetus infections.

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