An overview of the functions of p53 and drugs acting either on wild- or mutant-type p53

Yongmi Huang1, Zhihao Jiao1, Yuqing Fu1

  • 1Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, PR China.

Insights

The TP53 gene, or tumor protein 53, acts as a guardian of the genome. Research explores drugs to reactivate its function, offering new cancer treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The TP53 gene encodes the p53 protein, a critical tumor suppressor.
  • p53 monitors DNA damage, halting cell cycles for repair or inducing apoptosis.
  • TP53 mutations compromise these functions, contributing to various cancers.

Purpose of the Study:

  • To review drugs targeting wild-type and mutant TP53.
  • To summarize diverse strategies for discovering p53-acting drugs.
  • To aid researchers in selecting appropriate research directions for p53 drug development.

Main Methods:

  • Literature review of TP53-related drugs and cancer research.
  • Categorization of p53 into wild and mutant types.
  • Classification of drugs based on treatment strategies.

Main Results:

  • TP53 mutations are prevalent in major cancers like breast, colon, and lung.
  • Emerging drugs show potential in reactivating mutated p53.
  • p53 remains a key target for novel cancer therapies.

Conclusions:

  • TP53 is a vital gene in cancer suppression.
  • Targeting wild-type and mutant p53 represents a promising therapeutic avenue.
  • This review provides a framework for p53-focused drug design and research.

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