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Evaluation of atherosclerosis as a risk factor in COPD patients by measuring the carotid intima-media thickness

Ali Firincioglulari1, Hakan Erturk2, Mujgan Firincioglulari3

  • 1Department of Chest Diseases, Dr Burhan Nalbantoğlu State Hospital, Nicosia, Cyprus.

Cardiovascular Ultrasound
|January 9, 2024
PubMed

Insights

Atherosclerosis is more prevalent in Chronic Obstructive Pulmonary Disease (COPD) patients, with increased carotid intima-media thickness linked to hypoxemia and hypercapnia. Severity of COPD, hypoxemia, hypercapnia, and age are key factors in developing atherosclerosis in these patients.

Area of Science:

  • Cardiovascular Medicine
  • Pulmonology
  • Medical Imaging

Background:

  • Chronic Obstructive Pulmonary Disease (COPD) is often associated with comorbidities.
  • Atherosclerosis, a major cardiovascular disease, is a significant concern in COPD patients.

Purpose of the Study:

  • To evaluate atherosclerosis by measuring carotid intima-media thickness (CIMT) in COPD patients.
  • To assess the relationship between atherosclerosis and COPD prevalence, hypoxemia, and hypercapnia.

Main Methods:

  • A prospective case-control study involving 140 participants (70 COPD patients, 70 healthy controls).
  • Carotid intima-media thickness, radial arterial blood gas analysis, and spirometry were performed.
  • COPD diagnosis and severity assessment followed GOLD 2019 guidelines.

Main Results:

  • COPD patients exhibited significantly higher average CIMT (0.8746±0.161) and carotid bulb thickness (1.04±0.150) compared to controls.
  • Increased carotid thickness in COPD patients correlated significantly with hypoxemia (p<0.05) and hypercapnia (p<0.05).
  • Carotid intima-media thickness was higher in COPD patients with hypoxemia and hypercapnia, and correlated with COPD severity (p<0.05).

Conclusions:

  • Significant differences in carotid thickness were observed across COPD severity grades.
  • Elevated CIMT was noted even in the early stages of COPD.
  • COPD severity, hypoxemia, hypercapnia, and age are identified as determinants of atherosclerosis in COPD patients.
Abstract

Keywords:
AtherosclerosisCIMTCOPDCarotid BulbusStroke

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