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Related Experiment Videos

Glomerular function and morphology after renal mass reduction in dogs.

J J Bourgoignie, G Gavellas, E Martinez

    The Journal of Laboratory and Clinical Medicine
    |April 1, 1987
    PubMed
    Summary

    Severe kidney reduction in dogs led to increased proteinuria and glomerular damage. Some dogs experienced progressive decline in kidney function and worsening sclerosis over time.

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    Area of Science:

    • Nephrology
    • Comparative Pathology
    • Renal Physiology

    Background:

    • Rodent models of renal mass reduction show proteinuria, glomerular sclerosis, and declining GFR.
    • Investigating these effects in other species is crucial for understanding kidney disease progression.

    Purpose of the Study:

    • To determine if dogs subjected to significant renal mass reduction develop similar pathological changes and functional decline as observed in rodents.
    • To examine the long-term effects of reduced renal mass on proteinuria, glomerular structure, and glomerular filtration rate (GFR) in dogs.

    Main Methods:

    • Dogs underwent a seven-eighths reduction in renal mass and were fed a high-protein diet (26%).
    • Evaluated 24-hour proteinuria, glomerular structure, and fasting/postfeeding GFR in dogs.

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  • Monitored short-term (6 months) and long-term (18-39 months) outcomes in dogs with remnant kidneys.

    • Main Results:

    • Short-term: Modest increase in proteinuria (236 mg/24 hr) and development of mesangial hyperplasia or focal glomerular sclerosis in remnant kidneys.
    • Long-term: In some dogs, proteinuria progressed to 1-2 gm/24 hr, with glomerular pathology advancing to segmental sclerosis or diffuse obsolescence.
    • Long-term: A subset of dogs showed a progressive decline in fasting GFR starting 21-24 months post-reduction.

    Conclusions:

    • Subtotal nephrectomy in dogs can induce proteinuria and glomerular sclerosis, mirroring findings in rodents.
    • A significant proportion of dogs with reduced renal mass develop progressive proteinuria, glomerular pathology, and declining GFR over extended periods.
    • These findings highlight the dog as a relevant model for studying the long-term consequences of chronic kidney disease following renal mass reduction.