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A multicenter study of cervical cancer using quantitative diffusion-weighted imaging.

Xue Wang1, Zhijun Ye2, Shujian Li3

  • 1Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, PR China.

Acta Radiologica (Stockholm, Sweden : 1987)
|January 10, 2024
PubMed
Summary
This summary is machine-generated.

Quantitative diffusion-weighted imaging (DWI) metrics for cervical cancer show scanner variability. Perfusion parameters (D* and fD*) demonstrated higher consistency across different MRI scanners, suggesting their potential for reliable multicenter clinical use.

Keywords:
Quantitative imagingcervical cancerdiffusion-weighted imagingmulticenter study

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Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Diffusion-weighted imaging (DWI) parameters are increasingly used as biomarkers in cancer diagnosis and treatment monitoring.
  • The consistency of quantitative DWI measurements across different institutions is a critical, yet uncertain, factor for widespread clinical adoption.

Purpose of the Study:

  • To assess the consistency of quantitative metrics derived from DWI across multiple MRI scanners in a multicenter setting.
  • To evaluate the reliability of apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) parameters for cervical cancer imaging.

Main Methods:

  • Retrospective analysis of DWI data from 193 cervical cancer patients across four scanners at three centers.
  • Processing DWI data using mono-exponential and IVIM models to derive ADC, D, D*, f, and fD* parameters.
  • Comparative analysis of DWI parameters obtained from different MRI scanners.

Main Results:

  • Significant differences were observed in D and ADC parameters between certain scanners (P <0.01).
  • Perfusion parameters (D* and fD*) showed high consistency across all tested scanners (P >0.05).
  • Scanners from the same vendor and model exhibited close measurements for ADC and IVIM parameters.

Conclusions:

  • Scanners of the same model and vendor can provide consistent ADC and IVIM measurements.
  • Perfusion parameters derived from DWI exhibit superior consistency across different scanners, making them promising for multicenter studies in cervical cancer.