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Developmental Risk for Infants with Cleft Lip with or Without Cleft Palate Based on Caregiver-Proxy Reports

Kathleen A Kapp-Simon1,2, Meredith Albert1,2, Todd C Edwards3

  • 1Cleft/Craniofacial Center, Shriners Children's, Chicago, Chicago, IL, USA.

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
|January 10, 2024
PubMed

Insights

Infants with cleft lip and palate (CLP) and male infants show higher developmental risks, particularly in communication and motor skills. Regular developmental screening is crucial for early intervention in these high-risk populations.

Area of Science:

  • Pediatric Development
  • Craniofacial Anomalies
  • Developmental Pediatrics

Background:

  • Cleft lip ± alveolus (CL ± A) and cleft lip and palate (CLP) are common congenital anomalies affecting infant development.
  • Early identification of developmental risks is crucial for timely intervention and improved outcomes.

Purpose of the Study:

  • To assess caregiver-reported development in infants with CL ± A and CLP.
  • To identify factors associated with increased developmental risk.
  • To evaluate the consistency of developmental risk before and after cleft lip surgery.

Main Methods:

  • Prospective, longitudinal study assessing development at two time points: pre-surgery and 2 months post-surgery.
  • Utilized the Ages and Stages Questionnaire-3 (ASQ-3) across five developmental domains.
  • Included 123 caregivers reporting on infants from three US craniofacial centers and online support groups.

Main Results:

  • A significant proportion of infants with CL ± A and CLP did not pass all developmental domains at either time point (47% pre-surgery, 42% post-surgery).
  • Infants with CLP were at higher risk for communication and gross motor delays.
  • Male infants demonstrated increased risk in fine motor and problem-solving domains.

Conclusions:

  • Caregiver reports indicate a high rate of infants with CL ± A and CLP meeting developmental referral criteria.
  • Infants with CLP and male infants represent key subgroups at elevated developmental risk.
  • Routine developmental screening is recommended for infants with clefts to facilitate early support.

Keywords:
cleft lip and palatedevelopmental delayparental perception

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