Related Experiment Video

Updated: Jul 6, 2025

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

4.4K

Fifth-Generation Cephalosporins Is Not Spared From Drug-Induced Liver Injury

Monish A Sheth1,2

  • 1Internal Medicine, Baylor College of Medicine, Temple, USA.

Cureus
|January 10, 2024
PubMed

Insights

Ceftaroline, an antibiotic for skin infections, can cause liver injury (DILI) even after two doses. Stopping the drug resolved the injury, highlighting ceftaroline-induced liver injury as a potential concern.

Area of Science:

  • Pharmacology
  • Hepatology
  • Infectious Diseases

Background:

  • Ceftaroline fosamil is an FDA-approved cephalosporin antibiotic for acute bacterial skin and skin structure infections (ABSSSI).
  • Drug-induced liver injury (DILI) is a critical consideration for antibiotic safety profiles.
  • Early identification and management of DILI are essential for patient outcomes.

Observation:

  • A previously healthy individual developed DILI after receiving only two doses of ceftaroline.
  • The patient exhibited signs and symptoms consistent with liver injury shortly after antibiotic initiation.
  • Causality was assessed using the Roussel Uclaf Causality Assessment Method (RUCAM) score.

Findings:

  • Ceftaroline was identified as the causative agent for DILI in this case.
  • Discontinuation of ceftaroline led to a complete resolution of liver injury within three weeks.
  • Other potential causes of liver injury, including hemochromatosis, Wilson's disease, celiac disease, and thyroid disease, were systematically excluded.

Implications:

  • This case underscores the potential for ceftaroline to cause DILI, even with short-term use.
  • Clinicians should maintain a high index of suspicion for DILI in patients treated with ceftaroline.
  • Prompt recognition and drug withdrawal are crucial for managing ceftaroline-induced liver injury.
Keywords:
ceftarolinecellulitiscephalosporin induceddrug-induced liver injury (dili)herbal supplement adverse eventidiosyncratic hypersensitivity reactionlft - liver function testsrucam score

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