Current Perspectives: Obesity and Neurodegeneration - Links and Risks

Area of Science:

• Neuroscience
• Metabolic Health
• Public Health

Background:

• Obesity prevalence is rising globally across all age groups.
• Obesity contributes to metabolic and cardiovascular diseases via adipose, muscle, and liver tissue dysfunction.
• Pathological mechanisms include inflammation, oxidative stress, and mitochondrial dysfunction.

Purpose of the Study:

• To review the relationship between obesity, Alzheimer's disease (AD), and Parkinson's disease (PD).
• To explore potential causative mechanisms linking obesity to neurodegeneration.
• To discuss non-pharmacological interventions for obesity-related neurological conditions.

Main Methods:

• Literature review of clinical and preclinical findings.
• Analysis of pathological mechanisms connecting obesity and neurodegeneration.
• Exploration of non-pharmacological intervention strategies.

Main Results:

• Obesity is associated with diminished brain health and increased risk of AD and PD.
• Insulin resistance, common in obesity, is linked to both AD and PD.
• Causative mechanisms linking obesity to neurodegenerative diseases require further elucidation.

Conclusions:

• Obesity poses a significant risk factor for neurodegenerative diseases like AD and PD.
• Further research into the mechanistic links is crucial for developing effective interventions.
• Non-pharmacological approaches may offer promising avenues for managing obesity-related neurological risks.