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Structural basis for transcription activation by the nitrate-responsive regulator NarL

Dmytro Kompaniiets1, Lina He2,3, Dong Wang1

  • 1Section of Transcription & Gene Regulation, The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.

Nucleic Acids Research
|January 10, 2024
PubMed
Summary

Escherichia coli NarL (a nitrate-responsive transcription factor) activates gene expression through a novel mechanism, interacting with RNA polymerase alpha CTD at the yeaR promoter. This cryo-EM structure reveals a unique transcription activation complex (TAC) assembly.

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