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Updated: Jul 6, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Electrochemical decarboxylative alkylation of β-ketoacids with phenol derivatives
Shan Wang1, Zhaotian Wu1, Junqiang Li1
1School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu 212100, China. chemjiang@just.edu.cn.
Abstract:
An electrochemical method for the decarboxylative alkylation of β-ketoacids with phenol derivatives has been developed. The protocol was carried out in readily available unseparated cells at room temperature in the absence of catalysts and oxidants. The corresponding aryl ketones were obtained in satisfactory yields without additional electrolytes, and were easy to produce in gram-scale synthesis. Based on control experiments and cyclic voltammetry, a plausible reaction mechanism was proposed.
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