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Updated: May 5, 2026

Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes
Published on: June 25, 2017
In vivo techniques for assessment of insulin sensitivity and glucose metabolism
Margaret K Hahn1,2,3,4,5, Adria Giacca2,5,6, Sandra Pereira1,6
1Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Abstract:
Metabolic tests are vital to determine in vivo insulin sensitivity and glucose metabolism in preclinical models, usually rodents. Such tests include glucose tolerance tests, insulin tolerance tests, and glucose clamps. Although these tests are not standardized, there are general guidelines for their completion and analysis that are constantly being refined. In this review, we describe metabolic tests in rodents as well as factors to consider when designing and performing these tests.
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