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Updated: Jul 6, 2025

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Published on: June 10, 2021
Sustainable Synthesis of Indole-Substituted Densely Functionalized Pyrrole
Adithya Vinod1, H M Chandra Mouli1, Poulomi Pal2
1Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER) - Hajipur, Hajipur, Bihar, 844102, India.
Abstract:
A novel chromatography- and catalyst-free methodology has been developed for the synthesis of poly substituted pyrrole in good yields via a multicomponent reaction of arylglyoxal, 1,3-dicarbonyl, indole, and aromatic amine. This strategy provides various advantages such as simple experimental and workup procedures, mild reaction conditions, no added catalyst, use of green solvent, and simple purification procedure of pure product without using column chromatography. This green method offers a simple and highly effective strategy to synthesize a wide range of indole-pyrrole conjugates in a one-pot operation.
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