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TREMendous microglial effects on neurons

Xiao-Fen Chen1, Guojun Bu2

  • 1Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China; Shenzhen Research Institute of Xiamen University, Shenzhen, Guangdong 518063, China.

Immunity
|January 10, 2024
PubMed

Insights

The study reveals a new function for TREM2 (triggering receptor expressed myeloid 2) in brain development. This receptor, known for its Alzheimer's disease link, influences neuronal energy metabolism.

Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • Triggering receptor expressed myeloid 2 (TREM2) is primarily found in brain microglia.
  • TREM2 is significantly linked to the risk of developing Alzheimer's disease.
  • Its precise functions beyond microglial roles remain under investigation.

Purpose of the Study:

  • To investigate a previously unrecognized role of TREM2.
  • To explore TREM2's influence on neuronal bioenergetics during neural development.

Main Methods:

  • Utilized genetic models to study TREM2 function in vivo.
  • Employed advanced imaging and metabolic assays to assess neuronal bioenergetics.
  • Analyzed gene expression patterns related to TREM2 signaling.

Main Results:

  • Demonstrated that TREM2 plays a critical role in regulating neuronal energy metabolism.
  • Showcased TREM2's involvement in shaping neuronal bioenergetic profiles during development.
  • Identified specific pathways through which TREM2 impacts neuronal function.

Conclusions:

  • TREM2 has a novel function in modulating neuronal bioenergetics, extending beyond its known microglial roles.
  • Understanding this function provides new insights into brain development and potential therapeutic targets for neurological disorders.
  • This finding opens new avenues for research into TREM2's multifaceted roles in the central nervous system.

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