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Role of microRNA-146a in cancer development by regulating apoptosis

Keihan Kookli1, Kosar Torfi Soleimani2, Eman Fathy Amr3

  • 1International Campus, Iran University of Medical Sciences, Tehran, Iran.

Pathology, Research and Practice
|January 10, 2024
PubMed

Insights

MicroRNAs (miRNAs) like miR-146a are crucial in cancer development and cell death. Understanding miR-146a

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cancer remains a significant global health challenge despite advances in treatment.
  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression, often dysregulated in cancer.
  • MiR-146a is frequently overexpressed in tumors and linked to cancer cell apoptosis and progression.

Purpose of the Study:

  • To explore the role of miR-146a in regulating cancer cell apoptosis.
  • To investigate the potential of miR-146a as a therapeutic target for cancer treatment.
  • To review the biogenesis, function, and implications of miR-146a in cancer cell death and chemotherapy resistance.

Main Methods:

  • Literature review of studies on miR-146a, cancer, and apoptosis.
  • Analysis of miR-146a's involvement in various cell death pathways.
  • Investigation of exosomal miR-146a's impact on cancer cell apoptosis.

Main Results:

  • MiR-146a expression is correlated with pathological changes and apoptosis regulation in cancer cells.
  • Modulating miRNA expression, including miR-146a, shows promise in mitigating cancer.
  • Exosomal miR-146a may promote apoptosis and potentially overcome chemotherapeutic resistance.

Conclusions:

  • MiR-146a plays a significant role in cancer cell apoptosis and progression.
  • Targeting miR-146a presents a hopeful strategy for enhancing cancer therapy outcomes.
  • Further research into exosomal miR-146a could lead to novel approaches for combating cancer and drug resistance.
Keywords:
ApoptosisCancerChemoresistanceExosomeMicroRNA-146a

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