Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Catenins01:23

Catenins

2.3K
Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
2.3K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

8.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
8.9K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

8.8K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.8K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

7.4K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.4K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

5.8K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metformin Reduces the Incidence of Shoulder Stiffness After Arthroscopic RC Repair: Response.

The American journal of sports medicine·2026
Same author

Patellar luxation causes abnormal mechanical loading and joint destruction in the femoral-tibial joint.

Bone & joint research·2026
Same author

A Case for Survival Analysis in Shoulder Stiffness Research: Response.

The American journal of sports medicine·2026
Same author

Pharmacological Stimulator of Interferon Genes Activation Enhances Autophagy-Mediated Clearance of <italic>Mycobacterium tuberculosis</italic> in Human Macrophages.

Journal of innate immunity·2026
Same author

Corrigendum to "GBP1-CDK9-STAT3 signaling axis promotes osteosarcoma PD-L1 expression and immune escape" [Neoplasia 69 (2025) 101232].

Neoplasia (New York, N.Y.)·2026
Same author

Hydrogels Targeting Mechanical-biological signaling transitions of interleukin-33 alleviates intervertebral-disc degeneration.

Materials today. Bio·2026

Related Experiment Video

Updated: Jul 6, 2025

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

3.0K

Signalling interaction between β-catenin and other signalling molecules during osteoarthritis development.

Jing Feng1,2, Qing Zhang3, Feifei Pu1,2

  • 1Department of Orthopedics, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Cell Proliferation
|January 10, 2024
PubMed
Summary

Osteoarthritis (OA) involves the entire joint, not just

More Related Videos

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

7.9K
Reconstitution Of &#946;-catenin Degradation In Xenopus Egg Extract
09:41

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

Published on: June 17, 2014

12.1K

Related Experiment Videos

Last Updated: Jul 6, 2025

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

3.0K
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

7.9K
Reconstitution Of &#946;-catenin Degradation In Xenopus Egg Extract
09:41

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

Published on: June 17, 2014

12.1K

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Rheumatology

Background:

  • Osteoarthritis (OA) is a prevalent synovial joint disorder affecting multiple joints.
  • OA pathogenesis is now understood as a disease affecting the entire joint, not just 'wear and tear'.
  • Research utilizes genetic mouse models and ex vivo human tissues to investigate OA mechanisms.

Purpose of the Study:

  • To review recent advances in understanding the Wnt/β-catenin signaling pathway's role in OA pathogenesis.
  • To explore the interactions between β-catenin and other key signaling pathways in OA development.
  • To identify critical signaling pathways for novel OA therapeutic strategies.

Main Methods:

  • Literature review focusing on Wnt/β-catenin signaling in osteoarthritis.
  • Analysis of interactions between β-catenin and pathways including TGF-β, BMP, Notch, Ihh, NF-κB, and FGF.
  • Evaluation of genetic mouse models and ex vivo joint tissues from OA patients.

Main Results:

  • Multiple signaling pathways, including Wnt/β-catenin, are implicated in OA development.
  • β-catenin interacts with TGF-β, BMP, Notch, Ihh, NF-κB, and FGF pathways in the context of OA.
  • Understanding these complex interactions is crucial for identifying key OA pathogenesis drivers.

Conclusions:

  • The Wnt/β-catenin pathway plays a critical role in osteoarthritis pathogenesis.
  • Interactions of β-catenin with other signaling pathways form a complex gene regulatory network in OA.
  • Elucidating these pathways can lead to novel therapeutic interventions for osteoarthritis.