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Published on: June 12, 2021
Ultrasound-nanovesicles interplay for theranostics
Jingyi Liu1, Qing You2, Fuming Liang3
1CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Ultrasound enhances nanovesicle (NV) production and therapeutic efficacy for disease treatment and diagnosis. This review details how ultrasound improves NV generation, penetration, and combined diagnostic and therapeutic applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Medical Imaging and Diagnostics
- Therapeutics
Background:
- Nanovesicles (NVs) offer advantages in disease treatment and diagnosis, including vascular permeability, biocompatibility, and loading capacity.
- Limitations such as low yield, poor in vivo penetration, and complex preparation hinder NV applications.
- Ultrasound presents a safe, deep-penetrating external stimulus with potential to overcome traditional clinical medicine restrictions.
Purpose of the Study:
- To review nanovesicle (NV) classification, generation, and modification strategies.
- To highlight the impact of ultrasound on NV formation and properties.
- To summarize the enhanced diagnostic and therapeutic effects of combining NVs with ultrasound for various diseases.
Main Methods:
- Review of existing literature on nanovesicles and ultrasound applications.
- Analysis of ultrasound's role in NV generation, yield enhancement, and preparation simplification.
- Evaluation of NV-ultrasound synergy in sonodynamic therapy, sonogenetic regulation, and medical imaging.
Main Results:
- Ultrasound can drive NV generation, increase yield, and simplify preparation processes.
- Ultrasound provides direct therapeutic effects and intelligent control for enhanced NV efficacy.
- NVs improve targeting efficiency in ultrasound-based therapies and enhance imaging accuracy.
Conclusions:
- Ultrasound is a powerful tool to overcome nanovesicle limitations in yield and penetration.
- The combination of NVs and ultrasound significantly enhances disease treatment and diagnostic capabilities.
- This synergistic approach holds great promise for advancing clinical medicine.
