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Ultrasonography

Ultrasonography

Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...

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Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

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Ultrasound-nanovesicles interplay for theranostics.

Jingyi Liu¹, Qing You², Fuming Liang³

¹CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Advanced Drug Delivery Reviews

|January 10, 2024

Summary

Ultrasound enhances nanovesicle (NV) production and therapeutic efficacy for disease treatment and diagnosis. This review details how ultrasound improves NV generation, penetration, and combined diagnostic and therapeutic applications.

Keywords:

Deliver Diagnosis Disease Formation Nanovesicles Treatment Ultrasound

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Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

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Viral Nanoparticles for In vivo Tumor Imaging

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Published on: November 16, 2012

Area of Science:

Biomaterials Science
Nanotechnology
Medical Imaging and Diagnostics
Therapeutics

Background:

Nanovesicles (NVs) offer advantages in disease treatment and diagnosis, including vascular permeability, biocompatibility, and loading capacity.
Limitations such as low yield, poor in vivo penetration, and complex preparation hinder NV applications.
Ultrasound presents a safe, deep-penetrating external stimulus with potential to overcome traditional clinical medicine restrictions.

Purpose of the Study:

To review nanovesicle (NV) classification, generation, and modification strategies.
To highlight the impact of ultrasound on NV formation and properties.
To summarize the enhanced diagnostic and therapeutic effects of combining NVs with ultrasound for various diseases.

Main Methods:

Review of existing literature on nanovesicles and ultrasound applications.
Analysis of ultrasound's role in NV generation, yield enhancement, and preparation simplification.
Evaluation of NV-ultrasound synergy in sonodynamic therapy, sonogenetic regulation, and medical imaging.

Main Results:

Ultrasound can drive NV generation, increase yield, and simplify preparation processes.
Ultrasound provides direct therapeutic effects and intelligent control for enhanced NV efficacy.
NVs improve targeting efficiency in ultrasound-based therapies and enhance imaging accuracy.

Conclusions:

Ultrasound is a powerful tool to overcome nanovesicle limitations in yield and penetration.
The combination of NVs and ultrasound significantly enhances disease treatment and diagnostic capabilities.
This synergistic approach holds great promise for advancing clinical medicine.