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Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
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Synchronous myopia development induced by bilateral form deprivation in chicks.
Byung Soo Kang1, Tsz-Wing Leung2, Sonal Aswin Vyas3
1Centre for Eye and Vision Research Ltd, Hong Kong, China; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
Experimental Eye Research
|January 10, 2024
Summary
This study establishes a reliable bilateral form deprivation (FD) model in chicks to study myopia. Bilateral FD eyes showed synchronized growth and similar refractive errors to unilateral FD, confirming its feasibility for myopia research.
Area of Science:
- Ophthalmology
- Developmental Biology
- Animal Models
Background:
- Form deprivation (FD) is a common method for inducing myopia in animal models.
- Previous attempts at bilateral FD in chicks yielded inconsistent results.
- Unilateral FD models can be confounded by visual input from the fellow eye.
Purpose of the Study:
- To establish and validate a bilateral form deprivation (FD) myopia model in chicks.
- To investigate ocular growth patterns, feeding, and social behavior in this model.
- To assess the feasibility of bilateral FD for myopia research.
Main Methods:
- Bilateral or unilateral FD was induced in 6-day-old chicks for 12 days.
- Refractive error, corneal power, and ocular dimensions were measured periodically.
- Body weight and mortality were monitored to assess chick development and well-being.
Main Results:
- Bilateral FD chicks exhibited robust growth, comparable to unilaterally treated chicks.
- Both unilateral and bilateral FD induced significant myopia with similar refractive errors and axial elongation.
- Bilateral FD eyes showed thicker choroids and highly synchronized ocular biometric changes.
Conclusions:
- The bilateral FD paradigm is feasible for inducing myopia in chicks.
- This model demonstrates synchronized ocular growth, making it suitable for myopia research.
- The synchronized biometric changes in bilateral FD eyes confirm its reliability.
