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Updated: Jul 6, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

9.6K

Therapeutic potential of combating cancer by restoring wild-type p53 through mRNA nanodelivery

Divya Kamath1, Tomoo Iwakuma2, Stefan H Bossmann1

  • 1The University of Kansas Medical Center, Department of Cancer Biology, 3901 Rainbow Blvd, mailstop 1071, 66160 Kansas City, KS, USA.

Nanomedicine : Nanotechnology, Biology, and Medicine
|January 10, 2024
PubMed

Insights

TP53 mutations are common in cancer, leading to both loss of tumor suppression and new cancer-promoting functions. Restoring wild-type p53 (WTp53) function using mRNA nanomedicine offers promising new cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Nanomedicine

Background:

  • TP53 is the most frequently mutated tumor suppressor gene in human cancers.
  • Mutations often result in missense mutations, producing mutant p53 (mutp53) proteins.
  • mutp53 gains oncogenic functions that promote cancer metastasis and progression.

Purpose of the Study:

  • To review the role of TP53 mutations in cancer.
  • To explore the therapeutic potential of restoring wild-type p53 (WTp53) function.
  • To highlight advances in mRNA nanomedicine for cancer therapy.

Main Methods:

  • Literature review of TP53 mutation roles in cancer.
  • Discussion of therapeutic strategies targeting mutant p53.
  • Exploration of mRNA nanomedicine applications.

Main Results:

  • TP53 mutations lead to loss of tumor suppressor function and gain of oncogenic functions.
  • Current therapies targeting TP53 have limited success.
  • mRNA nanomedicine presents a novel approach for p53 restoration.

Conclusions:

  • Targeted therapies to restore WTp53 or deplete mutp53 are crucial for cancer treatment.
  • mRNA nanomedicine holds significant potential for restoring WTp53 function.
  • Advances in nanomedicine offer new avenues for effective cancer therapies.
Keywords:
Gene therapyNanotechnologyRestoring wild-type p53cancerp53 mutant

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