Redefining bioactive small molecules from microbial metabolites as revolutionary anticancer agents
Eileena F Giurini1, Aishvarya Godla1, Kajal H Gupta2,3
1Division of Surgical Oncology, Department of Surgery, Rush University Medical Center, Chicago, IL, 60612, USA.
Cancer Gene Therapy
|January 10, 2024
Summary
Microbial metabolites offer promising anticancer drugs, overcoming resistance and toxicity challenges in cancer treatment. This review explores their mechanisms, emerging therapies, and clinical potential for novel cancer drug discovery.
Area of Science:
- Microbiology
- Pharmacology
- Oncology
Background:
- Cancer treatment faces challenges like drug resistance and toxicity.
- Microbial secondary metabolites are a rich source of biologically active compounds.
- These metabolites show potential for developing novel anticancer therapies.
Purpose of the Study:
- To review the anticancer mechanisms of established microbial metabolites.
- To highlight emerging therapies and clinical candidates derived from microbial metabolites.
- To discuss challenges and future prospects in microbial-derived anticancer drug discovery.
Main Methods:
- Literature review of established microbial metabolites with anticancer properties.
- Analysis of their mechanisms of action against cancer cells.
- Examination of clinical trials and drug candidates targeting specific molecular pathways.
Main Results:
- Microbial metabolites exhibit diverse anticancer mechanisms.
- Several microbial-derived compounds are approved or in clinical trials.
- Insights into molecular targets and therapeutic potential are provided.
Conclusions:
- Microbial metabolites represent a significant reservoir for anticancer agents.
- Further research promises novel therapeutic strategies for cancer.
- Overcoming drug resistance and toxicity remains a key focus.
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