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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Longitudinal Research02:20

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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Factors Affecting Illness01:18

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When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
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Erikson's Theory on Socioemotional Development during Adulthood01:27

Erikson's Theory on Socioemotional Development during Adulthood

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Erik Erikson's theory of psychosocial development outlines a series of stages through which individuals progress across the lifespan. Each stage involves a psychosocial conflict that significantly influences personal growth and well-being. Three key stages — intimacy versus isolation, generativity versus stagnation, and integrity versus despair — highlight the developmental challenges faced in adulthood.
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Related Experiment Video

Updated: Jul 6, 2025

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Understanding the Causes of Frailty Using a Life-Course Perspective: A Systematic Review.

Antonio Barrera1, Leandro F M Rezende2, Angelo Sabag3

  • 1Faculty of Health Sciences, Universidad Internacional de Valencia (VIU), 46002 Valencia, Spain.

Healthcare (Basel, Switzerland)
|January 11, 2024
PubMed
Summary
This summary is machine-generated.

Preventing frailty in older adults may be possible through healthy lifestyle choices starting in early life and mid-adulthood. Maintaining a normal weight and being physically active are key factors.

Keywords:
agingbiasconfoundingfrailprevention

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Area of Science:

  • Gerontology
  • Public Health
  • Epidemiology

Background:

  • Frailty risk factors in early life and mid-adulthood are understudied.
  • Identifying these factors is crucial for timely intervention and prevention strategies.

Purpose of the Study:

  • To systematically review and identify early life and adulthood risk factors associated with the development of frailty.

Main Methods:

  • A systematic review of cohort studies with ≥10 years follow-up was conducted.
  • Searches were performed across Web of Science, Embase, and PubMed databases.
  • Risk of bias was assessed using a created confounding score.

Main Results:

  • 33 cohort studies met inclusion criteria; only 16 had low risk of confounding.
  • Normal weight, physical activity, and high fruit/vegetable intake were associated with lower frailty risk.
  • Avoiding smoking, excessive alcohol, and sugar/artificially sweetened drinks also reduced frailty risk.

Conclusions:

  • Adopting healthy lifestyle behaviors, akin to ideal cardiovascular health, may prevent or delay frailty in older adults.
  • Early and mid-adulthood lifestyle choices significantly impact long-term frailty risk.