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Novel and Innovative Hybrid Technique for Type A Aortic Dissection

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Hereditary Thoracic Aortic Diseases.

Gaia Spaziani¹, Francesca Chiara Surace², Francesca Girolami¹

¹Pediatric and Transition Cardiology, Meyer Children's Hospital IRCCS, 50139 Florence, Italy.

Diagnostics (Basel, Switzerland)

|January 11, 2024

Summary

Hereditary thoracic aortic diseases are a diverse group of conditions identified through advanced imaging and genetics. This review details their characteristics and management implications for patients.

Keywords:

aortic dilation genetics hereditary aortopathies multimodality imaging thoracic aortic disease

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Area of Science:

Cardiovascular Medicine
Genetics
Medical Imaging

Background:

Hereditary thoracic aortic diseases (HTADs) encompass a range of aortic anomalies.
Advances in imaging and genetic analysis have improved HTAD recognition.

Purpose of the Study:

To review the clinical, genetic, and imaging features of HTADs.
To discuss the diagnostic implications for patient counseling and management.

Main Methods:

Literature review of hereditary thoracic aortic diseases.
Synthesis of clinical, genetic, and imaging data.
Analysis of management strategies and counseling guidelines.

Main Results:

HTADs represent a heterogeneous group of genetic disorders affecting the aorta.
Distinct genetic mutations correlate with specific clinical and imaging phenotypes.
Early diagnosis impacts lifestyle recommendations (sports, pregnancy) and treatment decisions.

Conclusions:

Comprehensive understanding of HTADs is crucial for effective patient care.
Multidisciplinary management involving geneticists, cardiologists, and surgeons is recommended.
Personalized risk assessment guides therapeutic and surgical interventions.