Related Experiment Video

Updated: Jul 6, 2025

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
08:11

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

8.3K

Cellular Impacts of Striatins and the STRIPAK Complex and Their Roles in the Development and Metastasis in Clinical

Amber Xinyu Li1, Tracey A Martin1, Jane Lane1

  • 1Cardiff China Medical Research Collaborative, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.

Cancers
|January 11, 2024
PubMed

Insights

Striatins (STRNs) and striatin-interacting phosphatase and kinase (STRIPAK) complexes regulate cell functions. Their dysregulation is linked to cancer, showing diagnostic and prognostic value in various cancer types.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Striatins (STRNs) are primarily cytoplasmic proteins involved in cellular processes.
  • STRNs, alongside protein phosphatase 2A (PP2A), form the core of striatin-interacting phosphatase and kinase (STRIPAK) complexes.
  • STRIPAK complexes play critical roles in regulating cell cycle, growth, and motility.

Purpose of the Study:

  • To comprehensively review the roles of STRNs and core STRIPAK members in cancer malignancy.
  • To discuss the cellular and clinical significance of STRIPAK components in cancer development and progression.

Main Methods:

  • Literature review of studies on STRNs and STRIPAK complexes in cancer.
  • Analysis of research on the biological and cellular functions of STRIPAK members.
  • Synthesis of findings from clinical studies on STRIPAK components in cancerous tissues.

Main Results:

  • STRNs and STRIPAK members regulate key cellular functions, including cell cycle control, growth, and motility.
  • Dysregulation of these STRIPAK components is associated with cancer development.
  • Elevated expression of STRIPAK components in cancerous tissues indicates significant diagnostic and prognostic value.

Conclusions:

  • STRNs and STRIPAK complexes are increasingly recognized for their roles in cancer cells and clinical cancers.
  • STRIPAK components hold potential as biomarkers for cancer diagnosis, prognosis, and metastatic progression.
  • Further research into STRIPAK members offers insights into cancer malignancy from cellular and clinical viewpoints.
Keywords:
Hippo signallingSG2NASTRIPAKSTRN3STRN4Wnt/β-cateninapoptosisautophagycancercell cyclecell proliferationclinical cancercoiled-coil regiondiagnosiskinasesmetastasisphosphatasesprognosissignallingstriatinzinedin

More Related Videos

A Real-time Electrical Impedance Based Technique to Measure Invasion of Endothelial Cell Monolayer by Cancer Cells08:51

A Real-time Electrical Impedance Based Technique to Measure Invasion of Endothelial Cell Monolayer by Cancer Cells

Published on: April 1, 2011

27.4K
Isolation of Primary Human Colon Tumor Cells from Surgical Tissues and Culturing Them Directly on Soft Elastic Substrates for Traction Cytometry09:28

Isolation of Primary Human Colon Tumor Cells from Surgical Tissues and Culturing Them Directly on Soft Elastic Substrates for Traction Cytometry

Published on: June 4, 2015

15.6K

Related Concept Videos

Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.7K
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Destabilization of Microtubules01:45

Destabilization of Microtubules

The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...
2.7K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
13.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K