Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to the Skeletal System01:20

Introduction to the Skeletal System

5.7K
The skeletal system is the central framework of the body, consisting of different connective tissues: bones, cartilage, tendons, and ligaments.
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...
5.7K
Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

2.0K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond semen analysis: in men with normal semen parameters telomere attrition and oxidative imbalance distinguish those fertile from those with infertility.

Journal of translational medicine·2026
Same author

Pathophysiology-Based Classification of Male Infertility: Evidence from an 800-patient Prospective Cohort.

The Journal of clinical endocrinology and metabolism·2026
Same author

Diabetes and melanoma: Impact on prognosis and healthcare costs.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Semen Quality in Transgender Individuals Seeking Fertility Preservation.

Andrology·2026
Same author

Health Promotion for Sun Protection: A Community Approach in a Mountain Setting.

High altitude medicine & biology·2026
Same author

Laser-based therapies in the management of non-melanoma skin cancers: a narrative review.

Lasers in medical science·2026

Related Experiment Video

Updated: Jul 5, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.2K

Gender Differences in Soft Tissue and Bone Sarcoma: A Narrative Review.

Ilaria Cosci1, Paolo Del Fiore2, Simone Mocellin2,3

  • 1Veneto Institute of Oncology IOV-IRCCS, 35128 Padova, Italy.

Cancers
|January 11, 2024
PubMed
Summary

Childhood soft tissue sarcomas show a male sex predilection, suggesting biological sex differences influence incidence. Further research into these mechanisms is crucial for targeted prevention and treatment strategies.

Keywords:
gender differencessarcomasoft tissue cancer

More Related Videos

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

14.3K
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.1K

Related Experiment Videos

Last Updated: Jul 5, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.2K
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

14.3K
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.1K

Area of Science:

  • Oncology
  • Genetics
  • Epidemiology

Background:

  • Sarcomas are rare cancers originating from mesenchymal tissues, classified as bone or soft tissue sarcomas.
  • While often sporadic, sarcomas can arise from genetic predispositions or environmental factors.
  • Emerging evidence indicates a male sex predilection in various sarcomas, including childhood cases, particularly soft tissue sarcomas.

Purpose of the Study:

  • To review and highlight the underlying biological factors contributing to sex differences in soft tissue sarcoma incidence.
  • To inform future prevention and treatment strategies by understanding these gender-specific mechanisms.

Main Methods:

  • Literature review of studies investigating sex differences in sarcoma incidence.
  • Analysis of existing data on genetic and environmental factors related to sarcoma etiology.
  • Exploration of biological mechanisms potentially mediating gender-specific tumor development.

Main Results:

  • Childhood soft tissue sarcomas exhibit a notable male sex predilection.
  • Significant gender differences in sarcoma incidence are observed, especially in pediatric populations.
  • The biological underpinnings of these sex differences remain largely uncharacterized.

Conclusions:

  • Understanding the biological mechanisms driving sex differences in soft tissue sarcomas is critical.
  • This knowledge can guide the development of sex-specific approaches for sarcoma prevention and treatment.
  • Further research is warranted to elucidate these complex gender-related factors in sarcoma pathogenesis.