Evaluation of Three Imaging Methods to Quantify Key Events in Pelvic Bone Metastasis
Haejun Lee1, Tae Ran Ahn2, Kyung Hoon Hwang1
1Department of Nuclear Medicine, Gachon University Gil Hospital, Incheon 21565, Republic of Korea.
Cancers
|January 11, 2024
Summary
BLADE DWI offers superior image quality and higher ADC values for pelvic bone metastasis compared to RESOLVE DWI, though with longer scan times. Both methods effectively differentiate metastatic from benign lesions using quantifiable cut-off values.
Area of Science:
- Radiology
- Medical Imaging
- Oncology
Background:
- Pelvic bone metastases detection and characterization are crucial in oncology.
- Differentiating malignant bone lesions from benign conditions like red marrow hyperplasia can be challenging.
- Advanced MRI techniques offer potential for improved diagnostic accuracy.
Purpose of the Study:
- To compare Turbo Spin Echo Diffusion-Weighted Imaging in radial trajectory (BLADE DWI) with multi-shot echoplanar imaging (RESOLVE DWI) for pelvic bone metastasis.
- To assess the correlation between apparent diffusion coefficient (ADC) values from MRI and standardized uptake values (SUVs) from PET/CT.
- To compare imaging characteristics and diagnostic performance between BLADE DWI and RESOLVE DWI in distinguishing metastatic from benign bone lesions.
Main Methods:
- Retrospective analysis of 58 pelvic bone lesions (metastasis and red marrow hyperplasia) in 19 patients.
- Acquisition of 3.0 T MRI with BLADE/RESOLVE DWI sequences and F-18 FDG PET/CT.
- Measurement of ADC values (MRI) and SUVs (PET/CT), and assessment of MRI image quality, signal-to-noise ratio (SNR), and imaging time.
Main Results:
- BLADE DWI demonstrated significantly higher ADC values, improved anatomical depiction, and higher SNR compared to RESOLVE DWI (p < 0.05).
- Both BLADE and RESOLVE DWI showed high accuracy in differentiating bone metastasis from red marrow hyperplasia, with established cut-off ADC values.
- A poor correlation was observed between ADC values and SUVs (correlation coefficient 0.04–0.31).
Conclusions:
- BLADE DWI provides superior image quality and higher ADC values for pelvic bone lesions compared to RESOLVE DWI, despite longer acquisition times.
- Both BLADE and RESOLVE DWI are effective in differentiating bone metastasis from red marrow hyperplasia using quantifiable cut-off values.
- Further research is needed to reconcile discrepancies between PET and MRI quantitative parameters.
